Which patients with recurrent implantation failure after IVF benefit from PGD for aneuploidy screening?

Onm-8: Recurrent Implantation Failure in IVF/ICSI Cycle

The success of assisted reproduction, although gradually increasing over the years, is still less than satisfactory. Many couples have benefited from this treatment; many have also been left frustrated following multiple failed attempts (Bulent Urman et al. 2005). Repeated implantation failure (RIF), defined as three or more failed IVF attempts or failure of IVF after cumula- Abstracts of the 5...

Reduced plasma fibrinolytic potential in patients with recurrent implantation failure after IVF and embryo transfer.

BACKGROUND Recurrent implantation failure (RIF) following embryo transfer (ET) is a major continuing problem in IVF. Women with haemostatic defects may be at increased risk of miscarriage and preclinical pregnancy loss. The fibrinolytic system is considered, at present, the key to new thrombotic pathogenic mechanisms. Patients with unexplained recurrent miscarriage have an impairment of fibrino...

I-24: Recurrent Implantation Failure

Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...

Recurrent Implantation Failure Is More Frequently Seen in Female Patients with Poor Prognosis

An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n = 115) from women experiencing RIF and healthy controls. Using a sig...